@article {Peng1753, author = {Shichun Peng and Yilong Ma and Joseph Flores and David Eidelberg and Doris Doudet}, title = {Abnormal topography of cerebral glucose metabolism in parkinsonian macaques: A FDG PET study}, volume = {51}, number = {supplement 2}, pages = {1753--1753}, year = {2010}, publisher = {Society of Nuclear Medicine}, abstract = {1753 Objectives Non-human primate models of parkinsonism can be used to assess brain responses to experimental treatment. Using hemi-brain images from high resolution FDG PET, we have reported abnormal hemispheric patterns of glucose metabolism following1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration in macaque monkeys. This study examined the effect on whole brain metabolic activity. Methods Six macaques received IV MPTP injections to create bilateral nigro-striatal lesions. FDG PET scans were acquired on a HRRT camera in lesioned animals and in 7 normal controls. PET images were normalized into a macaque brain template. The two groups were compared on a voxel basis using statistical parametrical mapping (SPM) and spatial covariance analysis. Changes in regional metabolism and brain network expression were assessed in 5 of the 6 lesioned animals who were also scanned before MPTP injection. Results SPM revealed significant hypermetabolism (p\<0.001) bilaterally in the globus pallidus/thalamus, pons, brainstem and cerebellum, with smaller hypometabolism in the posterior parietal cortex of parkinsonian monkeys. Global metabolic values did not differ between the groups (p=0.2). Spatial covariance analysis revealed a significant pattern (PC1, 37.66\% variance accounted for) that was topographically similar to the SPM pattern. The expression of this parkinsonism-related metabolic pattern (PRP) was elevated in the MPTP animals relative to the controls (p\<0.0005). PRP elevation was also evident comparing the 5 monkeys before and after MPTP (p\<0.005). PRP scores did not differ between the 7 controls and the 5 monkeys scanned before MPTP. Conclusions We used a brain mapping approach to delineate abnormal glucose metabolism in MPTP-lesioned macaques. The topographic patterns in parkinsonian monkeys are symmetrical as seen in PD patients. FDG PET imaging may be valuable for quantifying regional brain function in animal models of parkinsonism. Research Support CIHR Team CTP-7985}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/51/supplement_2/1753}, eprint = {https://jnm.snmjournals.org/content}, journal = {Journal of Nuclear Medicine} }