RT Journal Article
SR Electronic
T1 Olfactory nerve scintigraphy in normal volunteer by per-nasal Tl-201 administration
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1747
OP 1747
VO 51
IS supplement 2
A1 Junichi Taki
A1 Masato Yamada
A1 Hideaki Shiga
A1 Takaki Miwa
A1 Kohshin Washiyama
A1 Hiroshi Wakabayashi
A1 Anri Inaki
A1 Seigo Kinuya
YR 2010
UL http://jnm.snmjournals.org/content/51/supplement_2/1747.abstract
AB 1747 Objectives At present, there is no method to visualize the olfactory nerve damage. The aim of this study was to assess whether olfactory nerve scinitigraphy by per-nasal cavity thallium-201 (Tl) administration is feasible or not. Methods 5 normal volunteer (5 male, aged 43 ± 8) were administered 18-37 MBq of Tl on the olfactory mucosa. 30-min and 24-hr after the tracer administration, SPECT/CT was performed. CT image from SPECT/CT was fused with MRI image that obtained separately, then SPECT/MRI fused image was generated. On the SPECT/MRI coronal and sagittal fused images, ROIs were set to cover the area of Tl administered on the olfactory mucosa with the 50% threshold of maximum count, and another ROI was set on the olfactory bulb. The % uptake of the Tl of the olfactory bulb (U) was calculated as: U = 100 (counts of the olfactory bulb / counts of the olfactory mucosa). Results There were no adverse side effects on odor detection ability and nasal mucosa in all subjects. At 30-min after Tl administration, most of the Tl activity was observed at the roof of nasal cavity, however, significant activity was observed in olfactory bulb at 24-hr. Quantitatively, olfactory bulb Tl uptake at 30-min was 10.8 ± 6.8 % and it increased significantly at 24-hr (24.3 ± 11.8 %, p<0.05). Conclusions Tl transport from olfactory mucosa to olfactory bulb was clearly observed in normal volunteer by per-nasal cavity administration of Tl, indicating the feasibility of olfactory nerve scintigraphy for the diagnosis of impaired olfactory nerve function due to such as trauma or infectious diseases