RT Journal Article
SR Electronic
T1 Influence of zinc on the biokinetics of I-131 and thyroid functions following lithium therapy
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1978
OP 1978
VO 50
IS supplement 2
A1 Dhawan, D
A1 Nair, P
A1 Chadha, V
A1 Bhalla, P
YR 2009
UL http://jnm.snmjournals.org/content/50/supplement_2/1978.abstract
AB 1978 Objectives The present study was designed to explore the potential of zinc in regulating 131I biokinetics and thyroid functions following lithium therapy. Methods Female sprague dawley rats weighing 110-140g were segregated into four groups viz. Group I-untreated controls, Group II(lithium treated- Li2CO3-1.1 g/kg diet), Group III(zinc treated-227 mg ZnSO4/L drinking water) and Group IV(combined treated). The treatments were given for time durations of 1, 2 and 4 months. Results Following intraperitoneal administration of 0.37 MBq carrier- free-131I, a significant depression in the thyroidal 131I uptake both at 2 and 24 hrs was observed following lithium treatment for all the durations which however was normalized following zinc treatment. Lithium treatment caused a significant elevation in the thyroidal biological half life of 131I which was attenuated following 2 and 4 months of zinc supplementation. Lithium supplementation for 2 and 4 months significantly decreased serum T3 and T4 levels which however were increased following zinc treatment. Lithium treatment for 4 months caused a significant decrease in the thyroidal activities of Na+ K+ ATPase and monoamine oxidase which were nearly normalized by zinc. Further, lithium treatment for 4 months raised thyroidal levels of lipid peroxidation and catalase which however were normalized by zinc. On the contrary, thyroidal levels of reduced glutathione and glutathione S transferase decreased significantly following 2 and 4 months of lithium treatment but were significantly increased by zinc. Conclusions The present study concludes that zinc supplementation is helpful in attenuating the adverse effects caused by lithium on thyroid functions and can effectively regulate the biokinetics of 131I following lithium therapy.