RT Journal Article
SR Electronic
T1 Dosimetry of 177Lu-DOTATATE administered into neuroendocrine tumors – An initial experience from India
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1854
OP 1854
VO 50
IS supplement 2
A1 Gupta, Santosh
A1 V, Meera
A1 Malhotra, A.
A1 Kumar, Prateek
A1 Bal, Chandersekhar
YR 2009
UL http://jnm.snmjournals.org/content/50/supplement_2/1854.abstract
AB 1854 Objectives Aim of this work was the calculation of radiation absorbed dose to lesion, kidneys, liver and spleen of patients affected by neuroendocrine tumors(NETs) treated with 177Lu-DOTATATE. Methods We enrolled eight patients (M/F:4/4 ) with mean age 40.25±15.54 affected by different types of NETs diagnosed with 68Ga-DOTANOC PET-CT and biochemical markers.For radiation protection of kidneys,amino acid mixture was infused to each patient 30 m prior to therapeutic dose.3700MBq to 7400MBq of 177Lu-DOTATATE was infused to each patient over 30 m.Each patients underwent nine whole Body Scan with Dual Head GE Mill VG Gamma Camera,at 30m(pre- void),4h,8h,12h,24h,48h, 96h,144h and 168h(Post- void) .Blood samples were taken at different time points post injection .Urine were collected at different time intervals post injection at 0-4h,4-8h, 8-12h,12- 24h and 24-48h .The organs involved in dosimetric calculation were lesion,kidney,liver and spleen. Dosimetric calculations were done using the OLINDA/EXM 1.0 software. Results 177Lu-DOTATATE showed a rapid urinary excretion within the first 4h after therapy,with 52.88% of the 177Lu-DOTATATE administered being excreted.A physiological uptake of 177Lu-DOTATATE was seen in all patients in Kidneys, liver and spleen.Radiation absorbed doses were calculated: 1.71±0.645mGy/MBq for Kidneys, 0.27±0.08mGy/MBq for liver,3.36±1.21mGy/MBq for Spleen and 0.059±0.049mGy/MBq for lesion. Conclusions 177Lu-DOTATATE is an effective radiopharmaceutical used in the treatment of NETs especially in inoperable and metastases. The radiation absorbed dose is acceptable and low for Kidneys.