PT  - JOURNAL ARTICLE
AU  - Lubberink, Mark
AU  - Wong, Yeun Ying
AU  - Knaapen, Paul
AU  - Raijmakers, Pieter
AU  - Luurtsema, Gert
AU  - Vonk-Noordegraaf, Anton
AU  - Lammertsma, Adriaan
TI  - Measurement of myocardial oxygen extraction fraction using bolus inhalation of 15O-oxygen and dynamic PET
DP  - 2009 May 01
TA  - Journal of Nuclear Medicine
PG  - 652--652
VI  - 50
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/50/supplement_2/652.short
4100  - http://jnm.snmjournals.org/content/50/supplement_2/652.full
SO  - J Nucl Med2009 May 01; 50
AB  - 652 Objectives The aim of this study was to determine accuracy of oxygen extraction fraction (OEF) measurements using either a single scan after bolus inhalation of 15O2 to determine OEF, flow (MBF), and perfusable tissue fraction (PTF) or a 15O2 scan combined with a separate H215O scan for determination of MBF and PTF. Methods Simulations were performed to assess accuracy and precision of OEF when determining (A) all parameters from 15O2, (B) OEF from 15O2 and MBF and PTF from H215O, and (C) all parameters from 15O2, but restricting MBF and PTF to within ±10% of values derived from H215O to account for minor changes between the scans. Three patients underwent a 10 min scan on an ECAT Exact HR+ scanner after bolus injection of 1.1 GBq H215O, two 10 min scans after bolus inhalation of ~ 1.4 GBq 15O2, and a 6 min static scan after bolus inhalation of ~ 0.8 GBq C15O for ROI definition. Results Simulations showed highest correlation between simulated and true OEF for model B (r2 0.96 vs. 0.56 and 0.88 for A and C, respectively), with no bias. If small differences in parameters were present between H215O and 15O2 scans, correlation was best for model C (r2 0.88 vs 0.56 and 0.82 for A and B). In patients best fits were obtained for model B. Whole myocardium test-retest accuracy of OEF was 14±7%. Conclusions Best accuracy and precision for myocardial OEF measurements following bolus inhalation of 15O2 are obtained when other necessary parameters, such as MBF, are derived from an additional H215O scan.