RT Journal Article
SR Electronic
T1 Clinical utilities of FDG-PET/CT in small cell lung cancer
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1791
OP 1791
VO 50
IS supplement 2
A1 Ishimori, Takayoshi
A1 Watanabe, Yuji
A1 Sakata, Chie
A1 Ichihashi, Shigeo
A1 Nakashita, Satoru
A1 Maki, Daisuke
A1 Yabuta, Minoru
A1 Arimoto, Maya
A1 Ikeda, Itaru
A1 Dodo, Yoshihiro
YR 2009
UL http://jnm.snmjournals.org/content/50/supplement_2/1791.abstract
AB 1791 Objectives Small cell lung cancer (SCLC) has the most aggressive clinical course of pulmonary tumor and is treated in a different way from non-SCLC. However, the clinical value of FDG-PET/CT is not well established in SCLC patients. The purpose of this study was to evaluate clinical usefulness of FDG-PET/CT in SCLC. Methods A total of 22 consecutive patients (pts) (20 males, 2 females, age 70.5±8.6) with histologically-proven SCLC who underwent FDG-PET/CT exam were included in this study. Fifteen pts underwent PET/CT scan prior to treatment, while 10 pts underwent scan after treatment. Among them, 3 pts underwent both pre- and post-treatment scans. The findings of PET/CT images were analyzed visually, and compared with the final diagnosis obtained after at least 6 months’ follow-up. Results Before treatment, intense FDG uptake (SUV=8.3±2.8) was seen in all of the primary tumors. The initial stages were limited disease in 9 pts and extensive disease in 6 pts. Although primary or metastatic tumors were equally visualized on PET/CT and CT images in 10 pts, discordant findings between PET/CT and CT were observed in 5 pts: FDG-avid bone metastases (mets) were missed on CT in 4 pts, and MRI-positive brain mets were missed on PET/CT in 1 pt. After treatment, discordant findings between PET/CT and CT were observed in 7 pts. PET/CT clarified inconclusive finding on CT images in 5 pts. FDG-avid bone mets were missed on CT in 1 pt, and MRI-positive brain mets were missed on PET/CT in 1 pt. Conclusions FDG-PET/CT was useful in evaluating primary, metastatic and recurrent SCLC. FDG-PET/CT had additional value over CT because distant mets to bone, etc. could be missed only with CT images.