TY - JOUR T1 - An adaptive approach to quantitative cardiac gated SPECT by noise modeling, scatter compensation, resolution restoration and inversion of the attenuated Radon transform in KL domain JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1495 LP - 1495 VL - 50 IS - supplement 2 AU - Yi Fan AU - Hongbing Lu AU - Jianqi Wang AU - Shuyi Wang AU - Zhengrong Liang Y1 - 2009/05/01 UR - http://jnm.snmjournals.org/content/50/supplement_2/1495.abstract N2 - 1495 Objectives We have successfully inverted the attenuated Radon transform in an adaptive KL domain. This work further considers Poisson noise, scatter and collimator response in the KL domain. Methods In the KL domain, the noise remains its Poisson nature and is accurately treated by an adaptive Wiener filter after Anscombe transform. Scatter contribution to the photopeak window is then estimated based on a modified triple energy-window acquisition strategy for each KL component. Each scatter-compensated KL component of the photopeak window is further subject to a depth-dependent deconvolution based on the distance-frequency relationship with measured response kernel. Finally, each 3-D deconvolved KL component is reconstructed by inverting the attenuated Radon transform and the 4-D SPECT image frames are obtained by corresponding adaptive inverse KL transform. Results The presented approach was tested by computer simulations using the NCAT digital phantom of 128 cubic array and clinical data of 64x32 projection array size over 64 views. Eight frames were simulated or acquired over a cardiac cycle. The simulated eight frames (each of 128 cubic array) were processed on a PC platform with 3GHz CPU speed in less than a half hour. The processing time for the clinical data was less than ten minutes. The reconstruction is very encouraging. Conclusions An analytical approach to fully 4-D quantitative cardiac gated SPECT is feasible with the highest computing speed. ER -