TY - JOUR T1 - Does resolution modeling during reconstruction improve the DAT measurement on a high resolution PET? JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 466 LP - 466 VL - 50 IS - supplement 2 AU - Claire Leroy AU - Maria-Joao Ribeiro AU - Florent Sureau AU - Eric Artiges AU - Vincent Brulon AU - Jean-Luc Martinot AU - Regine Trebossen AU - Claude Comtat Y1 - 2009/05/01 UR - http://jnm.snmjournals.org/content/50/supplement_2/466.abstract N2 - 466 Objectives Resolution modeling is known to improve quantification in small structures by reducing the partial-volume effects. The aim of this work is to assess the impact of a fast reconstruction including resolution modeling on the BPND of 11C-PE2I to DAT using the high resolution HRRT PET scanner (Siemens) in Human. Methods Fourteen healthy subjects were examined during one hour after injection of 11C-PE2I. ROI were delineated in striatum and cerebellum using T1 MRI images. Each PET acquisition was reconstructed twice using the ordinary Poisson OSEM algorithm with and without implementation of the resolution modeling during reconstruction. The number of OSEM iterations was determined such as to ensure convergence of the BPND in the striatum. The BPND was calculated in striatum using ROI and simplified method. Voxel-based BPND parametric maps were consecutively generated and normalized using SPM5 and 11C-PE2I templates. Paired t-tests between reconstructions were performed on ROI (p<0.05) and voxel-based (SPM5; p<0.05, FDR) approaches. Results 12 and 20 OSEM iterations (16 subsets) were chosen respectively without and with resolution modeling. Resolution modeling results in a 20 +/- 6 % BPND increase in the dorsal striatum and a 14 +/- 3.5 % in the ventral striatum. The SPM analysis shows significant increase of BPND in the dorsal and ventral striatum, the midbrain and the parahippocampal area. No difference in DAT-free regions was observed. Conclusions Resolution modeling during reconstruction increases consistently the BPND values in DAT-rich regions. This increase should allow the detection of small changes of biological parameters for clinical purpose. ER -