PT  - JOURNAL ARTICLE
AU  - Tolboom, Nelleke
AU  - van der Flier, Wiesje
AU  - Yaqub, Maqsood
AU  - Boellaard, Ronald
AU  - Blankenstein, Rien
AU  - Luurtsema, Gert
AU  - Windhorst, Bert
AU  - Scheltens, Philip
AU  - Lammertsma, Adriaan
AU  - van Berckel, Bart
TI  - Relationship of cerebrospinal fluid biomarkers with in vivo [11C]PIB and [18F]FDDNP binding
DP  - 2009 May 01
TA  - Journal of Nuclear Medicine
PG  - 423--423
VI  - 50
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/50/supplement_2/423.short
4100  - http://jnm.snmjournals.org/content/50/supplement_2/423.full
SO  - J Nucl Med2009 May 01; 50
AB  - 423 Objectives The purpose of this study was to investigate the relationship between cerebrospinal fluid (CSF) measurements of beta-amyloid1–42 (Aß42) and tau with both [11C]PIB and [18F]FDDNP binding in patients with Alzheimer’s disease (AD), mild cognitive impairment (MCI) and healthy controls. Methods [11C]PIB and [18F]FDDNP scans, together with a lumbar puncture, were obtained in 38 subjects (15 AD, 13 MCI, 10 controls). Pearson’s correlations coefficients and linear regression analyses were used to evaluate potential associations between both CSF measures and global binding of both [11C]PIB and [18F]FDDNP. Results For both [11C]PIB and [18F]FDDNP, correlations with CSF levels of Aβ42 (r=-0.71 and r=-0.37, respectively) and tau (r=0.58 and r=0.55, respectively; all p<0.001) were found across groups. Linear regression analyses showed that, adjusted for age, sex and diagnosis, global [11C]PIB uptake had an inverse association with Aβ42 CSF levels (b=-0.50, p<0.001), whilst there was a positive association (b=0.60, p<0.05) between global [18F]FDDNP binding and tau CSF levels. Conclusions The inverse association between [11C]PIB and CSF Aβ42 confirms the notion that [11C]PIB measures amyloid load in the brain. The positive association between [18F]FDDNP and CSF tau suggests that at least part of the specific signal of [18F]FDDNP in AD patients is due to tangles.