PT  - JOURNAL ARTICLE
AU  - Nishii, Ryuichi
AU  - Kagawa, Shinya
AU  - Higashi, Tatsuya
AU  - Kishibe, Yoshihiko
AU  - Iwasaki, Jinei
AU  - Uehara, Tomoya
AU  - Kobayashi, Masato
AU  - Nagamachi, Shigeki
AU  - Arano, Yasushi
AU  - Kawai, Keiichi
TI  - Comparison of system A and system L amino acid transports in human pancreas with C-11 MeAIB and C-11 MET PET study
DP  - 2009 May 01
TA  - Journal of Nuclear Medicine
PG  - 1727--1727
VI  - 50
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/50/supplement_2/1727.short
4100  - http://jnm.snmjournals.org/content/50/supplement_2/1727.full
SO  - J Nucl Med2009 May 01; 50
AB  - 1727 Objectives To clarify the difference between system A and L amino acid transport imaging in clinical PET, we analyze the pharmacokinetics and the parametric images of [N-methyl-11C]α-methylaminoisobutyric acid ([11C]-MeAIB) as a marker of system A transport and of [S-methyl-11C]-L-methionine ([11C]-MET) as a marker of system L. Methods Six normal healthy subjects received intravenous injection of both [11C]-MeAIB and [11C]-MET, respectively in other day, and dynamic and static PET images were obtained. Plasma and pancreas time-activity curve were analyzed graphically using pharmacokinetic modeling with 1 tissue-compartment modeling, followed by the voxel-based parametric image analysis. Results In both PET images, peak plasma accumulation were observed in 2 min after injection and decreased tri-exponentially, while pancreas showed constant increased uptake because of system A and L amino acid transports. In pharmacokinetic modeling from the time-activity curves, parameters of K1, K2 and Vt were 0.21±0.12, 0.10±0.06, 1.99±0.19 for [11C]-MeAIB and 0.44±0.05, 0.04±0.03, 10.46±4.32 for [11C]-MET, respectively (P<0.01). Conclusions System A and L amino acid transport image analysis were obtained with [11C]-MeAIB and [11C]-MET PET in human pancreas. These PET imaging would contribute to assess the activity of amino acid transports in various diseases such as neoplasm.