RT Journal Article
SR Electronic
T1 Dynamic brain imaging with low injection dose using the NeuroPET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 527
OP 527
VO 50
IS supplement 2
A1 William Worstell
A1 Stephen Adler
A1 Paul Domigan
A1 Olof Johnson
A1 Haris Kudrolli
A1 Piotr Kulinich
A1 John Nevin
A1 Leonid Romanov
A1 Colin Worth
YR 2009
UL http://jnm.snmjournals.org/content/50/supplement_2/527.abstract
AB 527 Objectives Perform dynamic PET studies of patients injected with low doses of F-18 and C-11 radiotracers with a dedicated 3D brain scanner: NeuroPET. Methods NeuroPET offers both high image quality and the potential to significantly reduce patient dose to enable safe multiple repeat scans of the same patient for longitudinal studies, response to therapies, or recurrence monitoring. This can be important in both research and clinical setting for natural history studies of disease progression, therapy trials, or clinical observation of response. A compact and moveable dedicated 3D brain scanner can be more easily sited than a general-purpose whole-body machine, at a fraction of the system cost. We have designed and built several such machines, and acquired human images which were reconstructed from list mode data. We collect list mode data incorporating measured energy and timing information on each coincidence event, plus a sampling of singles events. The former is useful for accurate background subtraction, while the latter is useful for run-specific (rate-dependent) normalization and live fraction corrections. While providing additional information to improve quantitative accuracy, this "extended list mode" data facilitates dynamic imaging of F18 and C11 tracers and offline re-analysis of research PET data. Results We demonstrate that the scanner is capable of making high quality dynamic brain images with a sub-milliCurie FDG patient dose. Conclusions NeuroPET, with its high sensitivity, high spatial resolution and flexible software, is an ideal PET scanner to perform dynamic brain imaging