PT  - JOURNAL ARTICLE
AU  - Zhan, Hongwei
AU  - Liu, Hongbiao
AU  - Bao, Chengkan
AU  - Zhang, Hong
TI  - Effect of carbogen on tumour oxygenation and 32P-colloid interstitial irradiation response
DP  - 2009 May 01
TA  - Journal of Nuclear Medicine
PG  - 1647--1647
VI  - 50
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/50/supplement_2/1647.short
4100  - http://jnm.snmjournals.org/content/50/supplement_2/1647.full
SO  - J Nucl Med2009 May 01; 50
AB  - 1647 Objectives To study the effects of long-term carbogen breathing on tumour oxygenation and 32P-colloid interstitial irradiation response in murine tumours. Methods 99mTc-HL91(99mTc 4,9-diaza-3,3,10,10-tetramethyldodecan-2,1-dione dioxime) hypoxic imaging was performed in 10 mice bearing sarcoma 180 (S180) before and after 2 h carbogen breathing. Radioactivity ratios of tumour to contralateral limbs (T/L) of the two imaging were calculated and compared. Mice bearing S180 were subjected to long-term carbogen breathing (2 h/day for 24 days), and were treated with or without 32P-colloid. Tumour growth rate was observed in the S180-bearing mice. Results T/L of 99mTc-HL91 uptake before and after carbogen breathing was 1.872±0.391 and 1.354±0.189, respectively (t=4.476, P<0.01). In mice in the 32P-treated air breathing group and 32P-treated carbogen breathing group, tumour growth rate did not differ on day 12 after 32P-colloid treatment, and on day 24, the tumour volume was 2.728±0.469 and 2.237±0.603 cm3 (t=2.128, P<0.05) respectively, with tumour mass being 2.437±0.447 and 1.965±0.538 g (t=2.134, P<0.05), respectively. Conclusions Long-term carbogen breathing can increase tumour oxygenation and enhance the therapeutic effect of 32P-colloid interstitial irradiation.