@article {Pugliese2017, author = {Paul Pugliese and William Wamp and Fritzgerald Leveque and Christopher Palestro and Kenneth Nichols}, title = {Effect of isotope specific uniformity correction on SPECT image quality}, volume = {50}, number = {supplement 2}, pages = {2017--2017}, year = {2009}, publisher = {Society of Nuclear Medicine}, abstract = {2017 Objectives To determine if an In-111, rather than vendor recommended Tc-99m, uniformity correction improves In-111 SPECT image quality. Methods 100M count In-111 \& Tc-99m uniformity corrections were acquired for a dual detector camera per vendor guidelines. A Jaszczak SPECT phantom was filled with 200 μCi In-111 in 80 mL water in 8, 12, 16 \& 25 mL cylindrical inserts. To simulate increasing amounts of potentially de-tuning counts, 1-8 mCi Tc-99m was placed in the 5,600 mL surrounding water bath in 5 separate experiments. SPECT was acquired at 128 projections for 1, 5 \& 10 sec/projection, using Tc-99m, then In-111, flood corrections. The 3 axial slices passing through the inserts were de-identified \& shown side by side with In-111 \& Tc-99m corrected images randomly displayed. Maximum intensity projection (MIP) cines for paired phantom tomograms were displayed side by side in random order. One experienced individual reviewed 44 paired axial images \& 15 paired MIP cines, indicating which, if either, image was of higher quality. Results For axial image pairs, the reader preferred In-111 corrected image 13 times, \& Tc-99m corrected image 14 times and had no preference 17 times. There was no tendency to chose 1 energy map over the other (p = NS). The reader indicated no preference between In-111 and Tc-99m in 14/15 MIP cines. Conclusions Data suggest that a Tc-99m correction flood can be used for In-111 SPECT studies, with no adverse impact on image quality. A separate In-111 correction flood is not necessary.}, issn = {0161-5505}, URL = {https://jnm.snmjournals.org/content/50/supplement_2/2017}, eprint = {https://jnm.snmjournals.org/content}, journal = {Journal of Nuclear Medicine} }