TY - JOUR T1 - Clinical evaluation of a local respiratory motion correction (LRMC) for PET/CT imaging JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1472 LP - 1472 VL - 50 IS - supplement 2 AU - Frederic Lamare AU - Ornella Rimoldi AU - Valentino Bettinardi AU - Paolo Camici AU - Dimitris Visvikis Y1 - 2009/05/01 UR - http://jnm.snmjournals.org/content/50/supplement_2/1472.abstract N2 - 1472 Objectives Although methodologies have been proposed to correct for respiratory movement the whole field of view (wFOV), they have not as such found wide acceptance in clinical routine. Advantages of LRMC include the use of a simple motion model, faster execution times and organ specific motion correction. The purpose of this study was to evaluate the performance of the LMRC using various motion compensation algorithms for cardiac and oncology (lung lesion) applications. Methods 4 preclinical cases and 6 human studies were used to evaluate the LMRC. PET data were acquired in list mode (LM) using the GE Discovery VCT and DRX PET/CT systems. An RPM device was used to synchronise the LM acquisitions with the respiration. The approach firstly consists in defining a VOI on the respiratory average image. Gated PET images of the VOI are subsequently reconstructed using only lines of response passing through the selected VOI and are used in combination with a centre of gravity or an affine/elastic registration algorithm to derive the transformation maps. Those are finally integrated during the reconstruction to produce a motion free image using all the detected statistics. Results The centre of gravity algorithm performs well for individual lesion motion correction, whereas an affine model was sufficient to compensate the heart for respiratory motion. Comparing the results on the lung lesions, a difference of <5% in SUVmean, <3% and 1% in the lesions size and position were calculated respectively. Conclusions This study indicates that the use of a local respiratory motion correction can be a flexible and efficient correction approach for single lesions or organs like the heart. ER -