TY - JOUR T1 - Dynamic imaging with a novel dedicated cardiac SPECT system JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 525 LP - 525 VL - 50 IS - supplement 2 AU - Qiu Huang AU - Rostyslav Boutchko AU - Bryan Reutter AU - Grant Gullberg Y1 - 2009/05/01 UR - http://jnm.snmjournals.org/content/50/supplement_2/525.abstract N2 - 525 Objectives Newly developed dedicated cardiac SPECT systems are ideal for performing dynamic cardiac SPECT imaging because they provide angular sampling and geometric efficiency sufficient to capture the blood input to the myocardium. In this work, the possibility of whether kinetic parameters in the myocardium (washin and washout rates) could be obtained from dynamically collected projections using a novel dedicated cardiac SPECT system was explored. Methods Using the NCAT digital phantom, a dynamic sequence of 33 activity distributions were generated as 80×80×40 volumes using the assumed time activity curves (TACs) of the washin and washout of 99mTc-teboroxime in the myocardium, the blood pool, and the liver. Projection data were then simulated with a system matrix that modeled the geometric properties of the ultra fast cardiac SPECT system "Discovery NM 530c" (DNM) designed by GE Healthcare. A factor analysis of dynamic structures (FADs) method was applied directly to the acquired projections to extract the TACs for the blood pool and the myocardium for 2 minutes of the acquisition. The two TACs were fit to a one-compartment model with a non-linear least squares fit method to estimate the washin and washout rate of 99mTc-teboroxime in the myocardium. Results The estimation of factors and factor coefficients (256066 unknowns) were calculated on a Pentium PC. The shape of the estimated TACs for the blood and the myocardium strongly resembles that of the simulated curves. Conclusions The simulations suggest that the FADs method is capable of extracting time activity curves directly from the acquired projectins and the DNM system can provide a parameteric image of flow times extraction for myocardial perfusion agents. ER -