PT  - JOURNAL ARTICLE
AU  - H Iida
AU  - T Zeniya
AU  - H Maruno
AU  - E Imabayashi
AU  - H Matsuda
AU  - K Ishida
AU  - M Nakazawa
AU  - H Watabe
AU  - T Akamatsu
TI  - Physical performance evaluation of quantitative SPECT reconstruction package – QSPECT
DP  - 2009 May 01
TA  - Journal of Nuclear Medicine
PG  - 1502--1502
VI  - 50
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/50/supplement_2/1502.short
4100  - http://jnm.snmjournals.org/content/50/supplement_2/1502.full
SO  - J Nucl Med2009 May 01; 50
AB  - 1502 Objectives QSPECT is a program to provide quantitative SPECT reconstruction for most of commercial cameras, distributed from Nihon-Medi Physics to contribute to clinical scans at 81 clinical institutions. The program compensates attenuation and scatter, providing quantitative images with reasonable accuracy with minimal enhancement of noise. This study was aimed at evaluating physical performance of this program. Methods Five SPECT cameras installed at 4 institutions were used, i.e., Toshiba 9300A fitted with LEHR and LMEGP collimators, GE Millenium VG with LEGP, two Siemens Symbia with LEHR and Toshiba 7200A with LEHR. Multiple rod sources in a 20cm diameter cylindrical were scanned with and without filling water to determine the spatial dependency of resolution. Uniformity was evaluated for pyramid and cylindrical phantoms for Tc-99m, I-123 and Tl-201. A realistic 3-dimensional brain phantom was for testing reproducibility among different SPECT systems. Results Image corresponded to radioactivity concentration in units of Bq/mL, agreed with true value <+/- 7.8%. Spatial resolution of 9.1-9.2 mm FWHM for LEHR collimator was independent of radial position, as a nature of the geometric-mean reconstruction. Image homogeneity was <3% in plane and axially for Tl-201, Tc—99m and I-123, using theoretical mu values. Realistic 3D brain phantom demonstrated agreement with the design, except for the magnitude of spatial smoothing. Conclusions After compensation for attenuation and scatter, SPECT images are consistent among different SPECT systems installed at different institutions, which is advantageous in multicenter clinical studies.