PT  - JOURNAL ARTICLE
AU  - Gorur, Gozde Daglioz
AU  - Tan, Yusuf Ziya
AU  - Oc, Alper
AU  - Isgoren, Serkan
AU  - Demir, Hakan
AU  - Berk, Fatma
TI  - Assessment of 24-hour thyroid uptake of I-131 sodium iodide using a 5-minute uptake of technetium-99m pertechnetate
DP  - 2009 May 01
TA  - Journal of Nuclear Medicine
PG  - 434--434
VI  - 50
IP  - supplement 2
4099  - http://jnm.snmjournals.org/content/50/supplement_2/434.short
4100  - http://jnm.snmjournals.org/content/50/supplement_2/434.full
SO  - J Nucl Med2009 May 01; 50
AB  - 434 Objectives This study is aimed to investigate the thyroid uptake of patients with hyperthyroidism using two different radio nuclides [sodium iodide (131I) and technetium 99m pertechnetate (99mTc)] and, develop a method to estimate the 24-hour 131I thyroid uptake based on a 5-minute 99mTc thyroid uptake Methods Ninety-nine patients with hyperthyroidism were investigated. Thirty-four patients were female, and sixty-five were male. First, 99mTc uptake (TcU) and thyroid scintigraphy were performed using the gamma camera (GC). 24-hour iodide uptake (IU) values were determined using uptake probe (UP), two days after the initial GC study. Results Mean age for the patients was 50 ± 16.4. Fifty percent of all patients had Grave’s disease (GD), 28 (28.3%) had toxic adenoma (TA), and 21 (21.2%) had toxic multi-nodular goiter (TMG). Mean TcU was found 7.15 ± 7.79. The IU values at 24 hours were 45.93 ± 15.4. The TcU, IU at 24 hours was higher in GD patients when compared to TA and TMG patients. TcU and 24-hour IU values demonstrated a strong logarithmical correlation (r= 0.61, p= 0.001). The formula used for estimation of IU was: y= 12.85Ln (x) + 26.07; where x represents TcU, and y represents IU at 24 hours. Conclusions TcU values can be easily be transformed to IU values, using the above mentioned formulas and these transformed values then used to calculate 131I treatment dose for patients with hyperthyroidism where speed and minimizing radiation dose are factors.