TY - JOUR T1 - New quantification algorithm of regional myocardial blood flow with 82Rubidium PET JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 384P LP - 384P VL - 49 IS - supplement 1 AU - Chietsugu Katoh AU - Keiichiro Yoshinaga AU - Osamu Manabe AU - Nagara Tamaki Y1 - 2008/05/01 UR - http://jnm.snmjournals.org/content/49/supplement_1/384P.3.abstract N2 - 1621 Objectives: It has been difficult to estimate regional myocardial blood flow (MBF) with 82Rb. We aimed to develop a new algorithm using a uniform input function which allowed stable quantification of regional MBF. We compared the estimates with a conventional one-compartment model analysis with no estimation of an appropriate input function. Methods: Twenty-one volunteers underwent at rest and pharmacological stress imaging with both 82Rb and 15O-water. We evaluated the relationship between the regional K1 of 82Rb and MBF with 15O-water. This algorithm includes a procedure for positioning a three-dimensional region of interest (ROI) of the whole myocardium and dividing it into 16 segments. The uniform input function was calculated using time-activity curves in the whole myocardial and left ventricular ROIs. The uniform input function allows simple algorithm to estimate regional K1, perfusable tissue fraction and spillover fraction with one-compartment model. These estimates were compared with those from the conventional method. A simulation study was performed to compare the effects of errors in the spillover fraction on the K1 using the two methods. Results: Our new method yielded more correlated regional K1 with MBF (K1(ml/min/g)= MBF(1-0.860exp(-0.543/MBF)), r=0.89) than the original method (r=0.37) (p<0.001). The new method yielded less deviated regional K1 within a subject (CV=25%) than the original method (CV=43%) (p<0.001). The simulation study demonstrated that 10% underestimation in the spillover fraction yielded 12% and 26% overestimation on the K1 value with the new and conventional methods, respectively. Conclusions: We have developed a new method for regional K1 estimation with 82Rb which is well correlated with 15O-water MBF. This algorithm is simple and more stable to estimate regional MBF rather than the conventional method. ER -