TY - JOUR T1 - Diagnostic value of statistical parametric mapping (SPM) in the interpretation of myocardial PET perfusion studies JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 384P LP - 384P VL - 49 IS - supplement 1 AU - Jonathon Nye AU - Nivedita Raghunath AU - John Votaw Y1 - 2008/05/01 UR - http://jnm.snmjournals.org/content/49/supplement_1/384P.2.abstract N2 - 1620 Objectives: Database quantification packages such as ECTb, AutoQuant and 4D-MSPECT are widely employed to improve the diagnostic accuracy of myocardial perfusion studies in nuclear imaging. The statistical parametric mapping (SPM) package offers additional capabilities including flexible test parameters, template construction and group comparisons. This study evaluates whether SPM can aid in the interpretation of PET adenosine-stress myocardial perfusion studies. Methods: Ten patients (8 male, 2 female) with less than 5% likelihood of coronary artery disease (CAD) based on sequential Bayesian analysis of age, gender, and symptom classification underwent Rb-82 adenosine-stress PET studies. Image data were registered and spatially normalized in the SPM5 package to construct a normal template. To demonstrate the principle, a male patient with known 40% left arterial descending (LAD) and 100% right coronary artery (RCA) disease (Cath > 50% for disease) was compared to the normal template. The test consisted of an independent two-sample equal variance student’s t-test of the adenosine-stress image reoriented and spatially normalized to the template. T-contrast volumes were generated, p-values calculated and the resulting significance data overlaid on the input image. Results: SPM found significantly lower (p<0.05) Rb-82 uptake in the vascular territory of the LAD. No significance was found in the vascular territories of the RCA or left circumflex (LCX). Conclusions: This work suggests that SPM is capable of detecting perfusion abnormalities in a subject of known disease when compared to a normal population. The potential diagnostic value of SPM in detecting myocardial perfusion defects warrants further validation studies on a population with known disease states. ER -