PT  - JOURNAL ARTICLE
AU  - Tinsu Pan
AU  - Lance Gould
AU  - Osama Mawlawi
AU  - Martha Mar
AU  - Eric Rohren
AU  - Homer Macapinlac
TI  - Investigation of helical CT with rigid body translation for attenuation correction of cardiac PET data
DP  - 2008 May 01
TA  - Journal of Nuclear Medicine
PG  - 390P--390P
VI  - 49
IP  - supplement 1
4099  - http://jnm.snmjournals.org/content/49/supplement_1/390P.1.short
4100  - http://jnm.snmjournals.org/content/49/supplement_1/390P.1.full
SO  - J Nucl Med2008 May 01; 49
AB  - 1643 Objectives: To investigate the application of helical CT with rigid body translation (RBT) for attenuation correction (AC) of cardiac PET data. Methods: Four patients were scanned with PET/CT and cine CT at the same imaging session on a GE Discovery ST PET/CT scanner. There was no known myocardium infarction or ischemia for the patients. There was misregistration of the heart between helical CT (HCT) and PET data in each patient. Average CT (ACT) from cine CT was able to correct for the false-positive deficit in the anterior (A) and anterior lateral (AL) walls most susceptible to the misalignment between the HCT data at end-inspiration and the PET data of average respiration. We designed software to overlay the HCT and PET images and applied RBT on HCT to cover the A and AL walls in PET data, and applied the HCT- RBT for AC of the PET data. The PET data corrected by ACT, HCT and HCT-RBT were quantitatively analyzed with quantitative perfusion software (QPS) of Hermes Medical Solutions. Results: Relative to ACT data, the maximum deficits with HCT in the A wall over three segments for the four patients were -16, -15, -17 and -29% and with the HCT-RBT were -7, 5, -18 and -4%. The deficits were -17, -17, -25 and -33% with HCT in the AL wall became -3, 3, -10 and -1% with HCT-RBT. There was improvement in reducing deficits in both walls with HCT-RBT over HCT. However, one anterior septal wall of one patient changed from 25% to -22% indicating a potential shift of deficit with HCT-RBT. Conclusions: RBT can improve the PET data of anterior and anterior lateral walls. However, some other area may be compromised by RBT.