RT Journal Article
SR Electronic
T1 Higher myocardial uptake of I-123 BMIPP immediately after reperfusion following no flow ischemia in isolated rat hearts
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 224P
OP 224P
VO 48
IS supplement 2
A1 Kenji Fukushima
A1 Mitsuru Momose
A1 Chisato Kondo
A1 Kiyoko Kusakabe
A1 Hiroshi Kasanuki
YR 2007
UL http://jnm.snmjournals.org/content/48/supplement_2/224P.2.abstract
AB 1067 Objectives: I-123 BMIPP (BMIPP) is a myocardial fatty acid analogue and is clinically useful for a detection of ischemia in patients with acute coronary syndrome compared to perfusion imaging agents. The aim of this study was to clarify the kinetics of BMIPP in acute reperfusion ischemia in isolated rat heart models. Methods: Isolated rat hearts, perfused by the Langendorff method at a constant flow rate of 10 mL/min, were allotted to the normal control (NG), mild ischemia (MG) and severe ischemia groups (SG), in which 20-min tracer washin was conducted followed by 25-min tracer washout. No-flow ischemia (15min for mild ischemia groups, 30min for severe ischemia groups) was induced before conducting washin-washout in the ischemia groups. Perfusion pressure and heart rate were monitored throughout the experiment. Whole heart radioactivity was determined with an external gamma detector. Tc-99m MIBI was used as a perfusion agent to compare to I-123 BMIPP kinetics. Myocardial uptake rate (K1 mL/min) and clearance rate (k2 /min) were calculated using a single compartment model analysis. Results: Perfusion pressure significantly increased and mean heart rate significantly decreased in severe ischemia groups (table). MIBI-K1 significantly decreased in ischemia, however BMIPP-K1 increased in ischemia groups and it showed inverse relation to severity of ischemia (figure). k2 did not show significant difference between normal and ischemia. Conclusions: Myocardial uptake of BMIPP was increased immediately after the reperfusion following no-flow ischemia, inversely related to the severity of ischemia. Clearance rate of BMIPP did not alter even under the severe ischemic condition. The increased metabolism may be due to a compensatory mechanism during the acute phase against severe ischemic myocardial damage. Perfusion pressure and mean heart rate in isolated rat heart