TY - JOUR T1 - Myocardial sympathetic innervation does not predict short-term cardiac events in patients with dilated cardiomyopathy: A study with I-123 MIBG SPECT JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 6P LP - 6P VL - 47 IS - suppl 1 AU - So Won Oh AU - Won Woo Lee AU - Yu Kyeong Kim AU - Xuan Canh Nguyen AU - Dong Joo Choi AU - Dong Soo Lee AU - June-Key Chung AU - Myung Chul Lee AU - Sang Eun Kim Y1 - 2006/05/01 UR - http://jnm.snmjournals.org/content/47/suppl_1/6P.3.abstract N2 - 17 Objectives: In order to investigate whether the myocardial sympathetic activity has a prognostic significance in dilated cardiomyopathy (DCMP), we evaluated myocardial sympathetic innervation in patients with DCMP using I-123 metaiodobenzylguanidine (MIBG) SPECT and compared with disease progression. Methods: I-123 MIBG SPECT was performed in 17 patients (age, 63.5±10.7 y; M/F = 11/6,) with DCMP (15 idiopathic and 2 ischemic). Both planar and SPECT myocardial images were acquired 15 min and 4 h after injection of 185 MBq I-123 MIBG. Heart-to-mediastium ratio (H/M) and washout rate (WR) were calculated on planar images. On SPECT images, total uptake score (TUS), defined as sum of myocardial segment uptake scores using a 20-segment and 3-point scale model, was calculated. Disease progression was defined as a decline of ejection fraction > 5% and/or hospitalization due to aggravation of dyspnea. The median follow-up period was 14.0 mo. Results: There was a significant inverse correlation between WR and TUS at 4 h (r = -0.705, P < 0.01). Five (29.4%) of the 17 patients had a disease progression during the median follow-up period of 13.1 mo. Cox proportion hazard regression analysis revealed no significant parameters for disease progression among variables including H/M, WR, TUS, and deltaTUS between 15 min and 4 h. Conclusions: These data indicate that the myocardial sympathetic activity measured by I-123 MIBG SPECT dose not predict short-term disease progression in patients with DCMP. ER -