RT Journal Article SR Electronic T1 An Exocrine Pancreatic Stress Test with 11C-Acetate PET and Secretin Stimulation JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1128 OP 1131 DO 10.2967/jnumed.113.135681 VO 55 IS 7 A1 Joo Hyun O A1 Martin A. Lodge A1 Sanjay Jagannath A1 Jonathan M. Buscaglia A1 Yetunde Olagbemiro A1 Richard L. Wahl YR 2014 UL http://jnm.snmjournals.org/content/55/7/1128.abstract AB The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function. Methods: In this pilot study, 5 healthy volunteers underwent two 60-min dynamic 11C-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed. Results: The baseline k1 and k2 data for all 5 volunteers were consistent. After secretin stimulation, the k1 and k2 significantly increased (paired t test P = 0.046 and P = 0.023, respectively). In the summed PET images, the pancreas-to-liver ratio decreased (P = 0.037). Increased 11C-acetate activity was observed in the duodenum after secretin stimulation consistent with secretin-induced secretion. Conclusion: 11C-acetate PET studies with secretin stimulation show potential as a noninvasive method for assessing pancreatic exocrine function.