TY - JOUR T1 - An Exocrine Pancreatic Stress Test with <sup>11</sup>C-Acetate PET and Secretin Stimulation JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1128 LP - 1131 DO - 10.2967/jnumed.113.135681 VL - 55 IS - 7 AU - Joo Hyun O AU - Martin A. Lodge AU - Sanjay Jagannath AU - Jonathan M. Buscaglia AU - Yetunde Olagbemiro AU - Richard L. Wahl Y1 - 2014/07/01 UR - http://jnm.snmjournals.org/content/55/7/1128.abstract N2 - The purpose of this study was to develop a noninvasive imaging test of pancreatic exocrine function. Methods: In this pilot study, 5 healthy volunteers underwent two 60-min dynamic 11C-acetate PET studies, one before and one after intravenous secretin administration. Kinetic analysis of the pancreas was performed using a 1-compartment model and an image-derived input function. From summed images, standardized uptake values were measured from the pancreas and the liver, and the pancreas-to-liver ratio was computed. Results: The baseline k1 and k2 data for all 5 volunteers were consistent. After secretin stimulation, the k1 and k2 significantly increased (paired t test P = 0.046 and P = 0.023, respectively). In the summed PET images, the pancreas-to-liver ratio decreased (P = 0.037). Increased 11C-acetate activity was observed in the duodenum after secretin stimulation consistent with secretin-induced secretion. Conclusion: 11C-acetate PET studies with secretin stimulation show potential as a noninvasive method for assessing pancreatic exocrine function. ER -