RT Journal Article SR Electronic T1 Preclinical and Translational PET/MR Imaging JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 11S OP 18S DO 10.2967/jnumed.113.129221 VO 55 IS Supplement 2 A1 Hans F. Wehrl A1 Stefan Wiehr A1 Mathew R. Divine A1 Sergios Gatidis A1 Grant T. Gullberg A1 Florian C. Maier A1 Anna-Maria Rolle A1 Johannes Schwenck A1 Wolfgang M. Thaiss A1 Bernd J. Pichler YR 2014 UL http://jnm.snmjournals.org/content/55/Supplement_2/11S.abstract AB Combined PET and MR imaging (PET/MR imaging) has progressed tremendously in recent years. The focus of current research has shifted from technologic challenges to the application of this new multimodal imaging technology in the areas of oncology, cardiology, neurology, and infectious diseases. This article reviews studies in preclinical and clinical translation. The common theme of these initial results is the complementary nature of combined PET/MR imaging that often provides additional insights into biologic systems that were not clearly feasible with just one modality alone. However, in vivo findings require ex vivo validation. Combined PET/MR imaging also triggers a multitude of new developments in image analysis that are aimed at merging and using multimodal information that ranges from better tumor characterization to analysis of metabolic brain networks. The combination of connectomics information that maps brain networks derived from multiparametric MR data with metabolic information from PET can even lead to the formation of a new research field that we would call cometomics that would map functional and metabolic brain networks. These new methodologic developments also call for more multidisciplinarity in the field of molecular imaging, in which close interaction and training among clinicians and a variety of scientists is needed.