PT  - JOURNAL ARTICLE
AU  - Hiroshi Ito
AU  - Hitoshi Shimada
AU  - Hitoshi Shinotoh
AU  - Harumasa Takano
AU  - Takeshi Sasaki
AU  - Tsuyoshi Nogami
AU  - Masayuki Suzuki
AU  - Tomohisa Nagashima
AU  - Keisuke Takahata
AU  - Chie Seki
AU  - Fumitoshi Kodaka
AU  - Yoko Eguchi
AU  - Hironobu Fujiwara
AU  - Yasuyuki Kimura
AU  - Shigeki Hirano
AU  - Yoko Ikoma
AU  - Makoto Higuchi
AU  - Kazunori Kawamura
AU  - Toshimitsu Fukumura
AU  - Éva Lindström Böö
AU  - Lars Farde
AU  - Tetsuya Suhara
TI  - Quantitative Analysis of Amyloid Deposition in Alzheimer Disease Using PET and the Radiotracer <sup>11</sup>C-AZD2184
AID  - 10.2967/jnumed.113.133793
DP  - 2014 Jun 01
TA  - Journal of Nuclear Medicine
PG  - 932--938
VI  - 55
IP  - 6
4099  - http://jnm.snmjournals.org/content/55/6/932.short
4100  - http://jnm.snmjournals.org/content/55/6/932.full
SO  - J Nucl Med2014 Jun 01; 55
AB  - Characteristic neuropathologic changes in Alzheimer disease (AD) are amyloid-β deposits and neurofibrillary tangles. Recently, a new radioligand for amyloid senile plaques, 11C-labeled 5-(6-{[tert-butyl(dimethyl)silyl]oxy}-1,3-benzothiazol-2-yl)pyridin-2-amine (11C-AZD2184), was developed, and it was reported to show rapid brain uptake followed by rapid washout. In this study, 11C-AZD2184 binding in control subjects and AD patients was examined in more detail by compartment model analysis using a metabolite-corrected arterial input function. The accuracy of simplified quantitative methods using a reference brain region was also evaluated. Methods: After intravenous bolus injection of 11C-AZD2184, a dynamic PET scan was obtained for 90 min in 6 control subjects and 8 AD patients. To obtain the arterial input function, arterial blood sampling and high-performance liquid chromatography analysis were performed. Results: Time–activity curves in all brain regions could be described using the standard 2-tissue-compartment model. The total distribution volume ratios to reference region (DVR) in cerebral cortical regions were significantly higher in AD patients than in control subjects. Although there was no conspicuous accumulation of radioactivity in white matter as compared with other amyloid radioligands, DVR values in the centrum semiovale were more than 1 for both control subjects and AD patients, suggesting binding to myelin. The standardized uptake value ratio calculated from integrated time–activity curves in brain regions and the reference region was statistically in good agreement with DVR. Conclusion: Although the white matter binding of 11C-AZD2184 may have some effect on cortical measurement, it can be concluded that the kinetic behavior of 11C-AZD2184 is suitable for quantitative analysis. The standardized uptake value ratio can be used as a validated measure of 11C-AZD2184 binding in clinical examinations without arterial input function.