TY - JOUR T1 - Prognostic Value of Metabolic Tumor Volume and Total Lesion Glycolysis on Preoperative <sup>18</sup>F-FDG PET/CT in Patients with Pancreatic Cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 898 LP - 904 DO - 10.2967/jnumed.113.131847 VL - 55 IS - 6 AU - Jeong Won Lee AU - Chang Moo Kang AU - Hye Jin Choi AU - Woo Jung Lee AU - Si Young Song AU - Jae-Hoon Lee AU - Jong Doo Lee Y1 - 2014/06/01 UR - http://jnm.snmjournals.org/content/55/6/898.abstract N2 - In this study, we aimed to assess the prognostic value of metabolic tumor volume (MTV) and total lesion glycolysis (TLG) measured on 18F-FDG PET/CT in pancreatic cancer patients who underwent resection with curative intent. Methods: Eighty-seven patients with pancreatic ductal adenocarcinoma who underwent 18F-FDG PET/CT and subsequent surgical resection with curative intent with (30 patients) or without (57 patients) neoadjuvant therapy were retrospectively enrolled. The maximum standardized uptake value (SUVmax), MTV, and TLG were measured on 18F-FDG PET/CT in all patients. The prognostic significances of PET/CT parameters and tumor factors for recurrence-free survival (RFS) and overall survival (OS) were evaluated by univariate and multivariate analyses. Results: Of the 87 patients, 57 (64%) experienced recurrence during the follow-up period. The tumor size, pathologic T (pT) stage, SUVmax, MTV, and TLG were significant prognostic factors for both RFS and OS (P &lt; 0.05) on univariate analyses, and the presence of lymph node metastasis showed significance only for predicting RFS (P &lt; 0.05). On multivariate analyses, the tumor size, MTV, and TLG were independent prognostic factors for RFS, and pT stage, MTV, and TLG were independent prognostic factors for OS. For the 57 patients who did not undergo neoadjuvant treatment, MTV and TLG remained significant predictive factors for tumor recurrence, along with tumor size and SUVmax. Conclusion: MTV and TLG are independent prognostic factors for predicting RFS and OS in patients with pancreatic cancer. Thus, 18F-FDG PET/CT can provide useful prognostic information for patients undergoing resection of pancreatic cancer with curative intent irrespective of neoadjuvant treatment. ER -