RT Journal Article
SR Electronic
T1 Multicenter Harmonization of <sup>89</sup>Zr PET/CT Performance
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 264
OP 267
DO 10.2967/jnumed.113.130112
VO 55
IS 2
A1 Makris, Nikolaos E.
A1 Boellaard, Ronald
A1 Visser, Eric P.
A1 de Jong, Johan R.
A1 Vanderlinden, Bruno
A1 Wierts, Roel
A1 van der Veen, Berlinda J.
A1 Greuter, Henri J.N.M.
A1 Vugts, Danielle J.
A1 van Dongen, Guus A.M.S.
A1 Lammertsma, Adriaan A.
A1 Huisman, Marc C.
YR 2014
UL http://jnm.snmjournals.org/content/55/2/264.abstract
AB This study investigated the feasibility of quantitative accuracy and harmonized image quality in 89Zr-PET/CT multicenter studies. Methods: Five PET/CT scanners from 3 vendors were included. 89Zr activity was measured in a central dose calibrator before delivery. Local activity assays were based on volume as well as on the local dose calibrator. Accuracy and image noise were determined from a cross calibration experiment. Image quality was assessed from recovery coefficients derived from different volume-of-interest (VOI) methods (VOIA50%, based on a 3-dimensional isocontour at 50% of the maximum voxel value with local background correction; VOIMax, based on the voxel with the highest uptake; and VOI3Dpeak, based on a spheric VOI of 1.2-cm diameter positioned so as to maximize the enclosed average). PET images were analyzed before and after postreconstruction smoothing, applied to match image noise. Results: PET/CT accuracy and image noise ranged from −3% to 10% and from 13% to 22%, respectively. VOI3Dpeak produced the most reproducible recovery coefficients. After calibration of the local dose calibrator to the central dose calibrator, differences between the local activity assays were within 6%. Conclusion: This study showed that quantitative accuracy and harmonized image quality can be reached in 89Zr PET/CT multicenter studies.