PT - JOURNAL ARTICLE AU - Daniel L.J. Thorek AU - Christopher C. Riedl AU - Jan Grimm TI - Clinical Cerenkov Luminescence Imaging of <sup>18</sup>F-FDG AID - 10.2967/jnumed.113.127266 DP - 2014 Jan 01 TA - Journal of Nuclear Medicine PG - 95--98 VI - 55 IP - 1 4099 - http://jnm.snmjournals.org/content/55/1/95.short 4100 - http://jnm.snmjournals.org/content/55/1/95.full SO - J Nucl Med2014 Jan 01; 55 AB - The aim of this study was to determine the feasibility of Cerenkov luminescence (CL) imaging of patients undergoing diagnostic 18F-FDG scans to detect nodal disease. Methods: Patients undergoing routine 18F-FDG PET/CT for various malignancies consented to being scanned for CL. White-light and Cerenkov images (5-min acquisition) of the surface of the patient contralateral to and at the site of nodal 18F-FDG uptake were acquired using a cooled, intensified charge-coupled-device camera. Results: The camera demonstrated linear correlation between activity and counts into the low nanocurie range using 18F-FDG. Imaging of patients revealed the presence of 18F-FDG uptake in nodes that demonstrated uptake on PET. A correlation between maximum standardized uptake value from PET and counting rate per area on the CL imaging was established. Conclusion: CL imaging with diagnostic doses of 18F-FDG is feasible and can aid in detecting disease in the clinical setting.