PT  - JOURNAL ARTICLE
AU  - André A. Neves
AU  - Kevin M. Brindle
TI  - Imaging Cell Death
AID  - 10.2967/jnumed.112.114264
DP  - 2014 Jan 01
TA  - Journal of Nuclear Medicine
PG  - 1--4
VI  - 55
IP  - 1
4099  - http://jnm.snmjournals.org/content/55/1/1.short
4100  - http://jnm.snmjournals.org/content/55/1/1.full
SO  - J Nucl Med2014 Jan 01; 55
AB  - There is currently a need for imaging methods capable of detecting cell death in tissues and the early onset of tumor cell death resulting from therapy. However, to date, no probe has been approved for routine imaging of cell death in the clinic. The challenge is to identify hallmarks of cell death, which have clinical relevance, and then to develop and validate imaging biomarkers for these hallmarks. We focus here on cell death imaging probes, which either have been trialed in the clinic or have significant promise, based on preclinical studies.