PT  - JOURNAL ARTICLE
AU  - Maarten L.J. Smits
AU  - Mattijs Elschot
AU  - Maurice A.A.J. van den Bosch
AU  - Gerrit H. van de Maat
AU  - Alfred D. van het Schip
AU  - Bernard A. Zonnenberg
AU  - Peter R. Seevinck
AU  - Helena M. Verkooijen
AU  - Chris J. Bakker
AU  - Hugo W.A.M. de Jong
AU  - Marnix G.E.H. Lam
AU  - Johannes F.W. Nijsen
TI  - In Vivo Dosimetry Based on SPECT and MR Imaging of <sup>166</sup>Ho-Microspheres for Treatment of Liver Malignancies
AID  - 10.2967/jnumed.113.119768
DP  - 2013 Dec 01
TA  - Journal of Nuclear Medicine
PG  - 2093--2100
VI  - 54
IP  - 12
4099  - http://jnm.snmjournals.org/content/54/12/2093.short
4100  - http://jnm.snmjournals.org/content/54/12/2093.full
SO  - J Nucl Med2013 Dec 01; 54
AB  - 166Ho-poly(l-lactic acid) microspheres allow for quantitative imaging with MR imaging or SPECT for microsphere biodistribution assessment after radioembolization. The purpose of this study was to evaluate SPECT- and MR imaging–based dosimetry in the first patients treated with 166Ho radioembolization. Methods: Fifteen patients with unresectable, chemorefractory liver metastases of any origin were enrolled in this phase 1 study and were treated with 166Ho radioembolization according to a dose escalation protocol (20–80 Gy). The contours of all liver segments and all discernible tumors were manually delineated on T2-weighted posttreatment MR images and registered to the posttreatment SPECT images (n = 9) or SPECT/CT images (n = 6) and MR imaging–based R2* maps (n = 14). Dosimetry was based on SPECT (n = 15) and MR imaging (n = 9) for all volumes of interest, tumor-to-nontumor (T/N) activity concentration ratios were calculated, and correlation and agreement of MR imaging– and SPECT-based measurements were evaluated. Results: The median overall T/N ratio was 1.4 based on SPECT (range, 0.9–2.8) and 1.4 based on MR imaging (range, 1.1–3.1). In 6 of 15 patients (40%), all tumors had received an activity concentration equal to or higher than the normal liver (T/N ratio ≥ 1). Analysis of SPECT and MR imaging measurements for dose to liver segments yielded a high correlation (R2 = 0.91) and a moderate agreement (mean bias, 3.7 Gy; 95% limits of agreement, −11.2 to 18.7). Conclusion: With the use of 166Ho-microspheres, in vivo dosimetry is feasible on the basis of both SPECT and MR imaging, which enables personalized treatment by selective targeting of inadequately treated tumors.