RT Journal Article SR Electronic T1 Acute Administration of Haloperidol Does Not Influence 123I-FP-CIT Binding to the Dopamine Transporter JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 647 OP 649 DO 10.2967/jnumed.113.132340 VO 55 IS 4 A1 Jan Booij A1 Guus van Loon A1 Kora de Bruin A1 Pieter Voorn YR 2014 UL http://jnm.snmjournals.org/content/55/4/647.abstract AB A recent 123I-FP-CIT (123-I-N-ω-fluoropropyl-2β-carbomethoxy-3β-(4-iodophenyl)nortropane) SPECT study on rats suggested that a single 1 mg/kg dose of the antipsychotic haloperidol induces enough dopamine release to compete with 123I-FP-CIT for binding to the dopamine transporter. Taking into account the far-reaching consequences of this proposition, we were interested in testing whether we could reproduce this finding using storage phosphor imaging. Methods: Twenty rats were pretreated with saline or haloperidol (1 mg/kg of body weight) and then injected with 123I-FP-CIT. Two hours after 123I-FP-CIT injection, the rats were sacrificed and binding in the striatum, nucleus accumbens, and cerebellum (nonspecific binding) was measured. Results: In contrast to the earlier SPECT finding, acute administration of haloperidol did not induce a significant change in 123I-FP-CIT binding ratios in the striatum and nucleus accumbens. Conclusion: Changes in synaptic dopamine due to acute haloperidol administration were not detectable with 123I-FP-CIT.