RT Journal Article
SR Electronic
T1 Comparative Biodistribution and Radiation Dosimetry of <sup>68</sup>Ga-DOTATOC and <sup>68</sup>Ga-DOTATATE in Patients with Neuroendocrine Tumors
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1755
OP 1759
DO 10.2967/jnumed.113.120600
VO 54
IS 10
A1 Mattias Sandström
A1 Irina Velikyan
A1 Ulrike Garske-Román
A1 Jens Sörensen
A1 Barbro Eriksson
A1 Dan Granberg
A1 Hans Lundqvist
A1 Anders Sundin
A1 Mark Lubberink
YR 2013
UL http://jnm.snmjournals.org/content/54/10/1755.abstract
AB 68Ga-DOTATOC and 68Ga-DOTATATE are 2 radiolabeled somatostatin analogs for in vivo diagnosis of neuroendocrine tumors with PET. The aim of the present work was to measure their comparative biodistribution and radiation dosimetry. Methods: Ten patients diagnosed with neuroendocrine tumors were included. Each patient underwent a 45-min dynamic and 3 whole-body PET/CT scans at 1, 2, and 3 h after injection of each tracer on consecutive days. Absorbed doses were calculated using OLINDA/EXM 1.1. Results: Data from 9 patients could be included in the analysis. Of the major organs, the highest uptake at 1, 2, and 3 h after injection was observed in the spleen, followed by kidneys and liver. For both tracers, the highest absorbed organ doses were seen in the spleen and urinary bladder wall, followed by kidney, adrenals, and liver. The absorbed doses to the liver and gallbladder wall were slightly but significantly higher for 68Ga-DOTATATE. The total effective dose was 0.021 ± 0.003 mSv/MBq for both tracers. Conclusion: The effective dose for a typical 100-MBq administration of 68Ga-DOTATATE and 68Ga-DOTATOC is 2.1 mSv for both tracers. Therefore, from a radiation dosimetry point of view, there is no preference for either tracer for PET/CT evaluation of somatostatin receptor–expressing tumors.