PT - JOURNAL ARTICLE AU - Chaofeng Huang AU - Jonathan McConathy TI - Radiolabeled Amino Acids for Oncologic Imaging AID - 10.2967/jnumed.112.113100 DP - 2013 Jul 01 TA - Journal of Nuclear Medicine PG - 1007--1010 VI - 54 IP - 7 4099 - http://jnm.snmjournals.org/content/54/7/1007.short 4100 - http://jnm.snmjournals.org/content/54/7/1007.full SO - J Nucl Med2013 Jul 01; 54 AB - Radiolabeled amino acids (AAs) are an important class of imaging agents for PET and SPECT that target the increased levels of AA transport by many tumor cells. System L AA transport has been a major focus of tracer development, and work in this field has led to several tracers that are effective for imaging brain tumors. Emerging data also support the use of certain radiolabeled AAs for neuroendocrine tumors and prostate cancer. Recently, new 18F-labeled AAs have been developed that target transporters other than system L, including system A, glutamine, xCT, and cationic AA transporters. This review provides an overview of this class of molecular imaging agents and highlights the current status of oncologic imaging with radiolabeled AAs in terms of tracer considerations and key clinical applications.