RT Journal Article SR Electronic T1 The Growing Impact of Bioorthogonal Click Chemistry on the Development of Radiopharmaceuticals JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 829 OP 832 DO 10.2967/jnumed.112.115550 VO 54 IS 6 A1 Dexing Zeng A1 Brian M. Zeglis A1 Jason S. Lewis A1 Carolyn J. Anderson YR 2013 UL http://jnm.snmjournals.org/content/54/6/829.abstract AB Click chemistry has become a ubiquitous chemical tool with applications in nearly all areas of modern chemistry, including drug discovery, bioconjugation, and nanoscience. Radiochemistry is no exception, as the canonical Cu(I)-catalyzed azide-alkyne cycloaddition, strain-promoted azide-alkyne cycloaddition, inverse electron demand Diels-Alder reaction, and other types of bioorthogonal click ligations have had a significant impact on the synthesis and development of radiopharmaceuticals. This review will focus on recent applications of click chemistry ligations in the preparation of imaging agents for SPECT and PET, including small molecules, peptides, and proteins labeled with radionuclides such as 18F, 64Cu, 111In, and 99mTc.