TY - JOUR T1 - Enriching the Interventional Vision of Cancer with Fluorescence and Optoacoustic Imaging JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 664 LP - 667 DO - 10.2967/jnumed.111.099796 VL - 54 IS - 5 AU - P. Beatriz Garcia-Allende AU - Jürgen Glatz AU - Maximilian Koch AU - Vasilis Ntziachristos Y1 - 2013/05/01 UR - http://jnm.snmjournals.org/content/54/5/664.abstract N2 - Among several techniques considered for surgical and endoscopic imaging, novel optical methods are evolving as a promising approach for interventional guidance. Pilot clinical applications of fluorescence molecular imaging have demonstrated the benefits of using targeted fluorescent agents in cancer surgery. This premise can be extended broadly to interventional guidance through an increasing number of targeted agents and detection techniques. Beyond epi-illumination fluorescence imaging, optoacoustic (photoacoustic) methods are emerging to offer high-resolution cross-sectional optical imaging through several millimeters to centimeters of depth. We present an overview of key recent developments in optical interventional imaging and outline the potential for a paradigm shift in surgical and endoscopic visualization. ER -