RT Journal Article SR Electronic T1 Hypermetabolism in 18F-FDG PET Predicts Favorable Outcome Following Decompressive Surgery in Patients with Degenerative Cervical Myelopathy JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1577 OP 1583 DO 10.2967/jnumed.112.113183 VO 54 IS 9 A1 Frank W. Floeth A1 Norbert Galldiks A1 Sven Eicker A1 Gabriele Stoffels A1 Jörg Herdmann A1 Hans-Jakob Steiger A1 Gerald Antoch A1 Sascha Rhee A1 Karl-Josef Langen YR 2013 UL http://jnm.snmjournals.org/content/54/9/1577.abstract AB The aim of this study was to prospectively assess the regional changes of glucose metabolism of the cervical spinal cord in patients with degenerative cervical spine stenosis and symptomatic cervical myelopathy after decompressive surgery using 18F-FDG PET. Methods: Twenty patients with symptomatic degenerative monosegmental cervical stenosis with neuroradiologic signs of spinal cord compression underwent decompressive surgery. The clinical course using a functional status score (Japanese Orthopedic Association [JOA] score), 18F-FDG uptake, and MR imaging were assessed before and at follow-up 12 mo after surgery. Pre- and postoperative changes of 18F-FDG PET were correlated to the patients’ clinical outcome. Results: Ten patients demonstrated preoperatively a focally increased 18F-FDG uptake at the level of the stenosis. At follow-up, the uptake declined significantly (P = 0.008), and a significant improvement of JOA scores (P < 0.001) could be observed. The remaining 10 patients were characterized preoperatively by an inconspicuous glucose uptake at the level of cord compression in combination with a poststenotic decrease of 18F-FDG uptake. At follow-up, both JOA scores and 18F-FDG uptake changed insignificantly. Conclusion: Focal glucose hypermetabolism at the level of cervical spinal cord compression may predict an improved outcome after surgical decompression. Thus, this finding on 18F-FDG PET suggests a functional damage in a reversible phase of cervical myelopathy.