PT  - JOURNAL ARTICLE
AU  - Brian D. Wright
AU  - Suzanne E. Lapi
TI  - Designing the Magic Bullet? The Advancement of Immuno-PET into Clinical Use
AID  - 10.2967/jnumed.113.126086
DP  - 2013 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1171--1174
VI  - 54
IP  - 8
4099  - http://jnm.snmjournals.org/content/54/8/1171.short
4100  - http://jnm.snmjournals.org/content/54/8/1171.full
SO  - J Nucl Med2013 Aug 01; 54
AB  - The development of noninvasive imaging techniques using monoclonal antibodies (mAbs) is a quickly evolving field. Immuno-PET uses positron-emitting isotopes to track the localization of mAbs with excellent image quality. Procedures for labeling mAbs with 89Zr or 124I using good manufacturing procedures have been established, and therefore these radiopharmaceuticals are being investigated for clinical use. This short review will focus on immuno-PET with full mAbs using long-lived positron-emitting isotopes (89Zr and 124I) over the past 5 y and discuss their progress into clinical use.