PT  - JOURNAL ARTICLE
AU  - Wong, Ka Kit
AU  - Piert, Morand
TI  - Dynamic Bone Imaging with <sup>99m</sup>Tc-Labeled Diphosphonates and <sup>18</sup>F-NaF: Mechanisms and Applications
AID  - 10.2967/jnumed.112.114298
DP  - 2013 Apr 01
TA  - Journal of Nuclear Medicine
PG  - 590--599
VI  - 54
IP  - 4
4099  - http://jnm.snmjournals.org/content/54/4/590.short
4100  - http://jnm.snmjournals.org/content/54/4/590.full
SO  - J Nucl Med2013 Apr 01; 54
AB  - Dynamic bone scanning with 99mTc-labeled diphosphonates and 18F-labeled sodium fluoride provides functional information sensitive for subtle changes in bone turnover and perfusion, which assists the clinical management of numerous osseous pathologies. This article reviews the mechanisms of uptake of 99mTc-labeled diphosphonates and 18F-sodium fluoride and discusses and compares the performance of these bone-seeking radiotracers for clinical and research applications, using dynamic and multiple-time-point imaging protocols and quantitative techniques.