RT Journal Article
SR Electronic
T1 Nigrostriatal Dopamine Terminal Imaging with Dopamine Transporter SPECT: An Update
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1331
OP 1338
DO 10.2967/jnumed.112.105379
VO 54
IS 8
A1 Klaus Tatsch
A1 Gabriele Poepperl
YR 2013
UL http://jnm.snmjournals.org/content/54/8/1331.abstract
AB This article gives an update on nigrostriatal dopamine terminal imaging, with emphasis on SPECT performed with the presynaptic dopamine transporter (DAT) ligand 123I-FP-CIT. The paper covers the rational use of this technique in the diagnostic work-up of patients with known or suspected parkinsonian syndromes. In detail, it addresses the impact of the method for the proof or exclusion of neurodegenerative parkinsonism, for its early and preclinical diagnosis, and for the evaluation of disease progression. The importance of normal DAT binding for differentiating symptomatic parkinsonism and relevant tremor syndromes from neurodegeneration is highlighted. Particularly emphasized is the role of DAT SPECT for diagnosing Lewy body dementia and its separation from Alzheimer dementia. Finally, some remarks deal with the economic aspects of the use of these imaging techniques in the clinical setting.