PT  - JOURNAL ARTICLE
AU  - Christian Lohrmann
AU  - Oliver Hauschild
AU  - Philipp T. Meyer
AU  - Michael Mix
AU  - Peter C. Strohm
AU  - Wolfgang A. Weber
AU  - Hans-Christian Rischke
TI  - Hybrid Imaging of Peripheral Skeletal Disease by SPECT/High-Resolution Flat-Panel CT
AID  - 10.2967/jnumed.112.116343
DP  - 2013 Aug 01
TA  - Journal of Nuclear Medicine
PG  - 1323--1326
VI  - 54
IP  - 8
4099  - http://jnm.snmjournals.org/content/54/8/1323.short
4100  - http://jnm.snmjournals.org/content/54/8/1323.full
SO  - J Nucl Med2013 Aug 01; 54
AB  - The aim of this study was to determine the impact of high-resolution cone-beam CT with flat-panel detectors on the interpretation of bone SPECT in diseases of the peripheral skeleton. Methods: Forty-one consecutive patients with peripheral skeletal disease were examined with a SPECT/high-resolution CT system providing isotropic voxels of 0.33 × 0.33 × 0.33 mm. High-resolution images were retrospectively analyzed by 2 readers and compared with low-resolution images obtained by filtering the high-resolution images to a lower resolution. Results: SPECT/high-resolution CT demonstrated higher diagnostic confidence scores (1.98 ± 0.27 vs. 1.3 ± 0.45, P < 0.01) and better interobserver agreement (κ = 0.5 vs. 0.2) than SPECT/low-resolution CT. The diagnosis made by SPECT/high-resolution CT was in agreement with the final clinical diagnosis in 95% (reader 1) and 90% (reader 2) of the cases, as compared with 59% (reader 1) and 60% (reader 2) of the cases for SPECT/low-resolution CT (P < 0.01). Conclusion: High-resolution flat-panel CT has the potential to significantly improve SPECT/CT imaging in diseases of the peripheral skeleton.