RT Journal Article
SR Electronic
T1 Pilot Study on the Feasibility of PET/CT Lymphoscintigraphy with <sup>89</sup>Zr-Nanocolloidal Albumin for Sentinel Node Identification in Oral Cancer Patients
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 585
OP 589
DO 10.2967/jnumed.112.115188
VO 54
IS 4
A1 Heuveling, Derrek A.
A1 van Schie, Annelies
A1 Vugts, Danielle J.
A1 Hendrikse, N. Harry
A1 Yaqub, Maqsood
A1 Hoekstra, Otto S.
A1 Karagozoglu, K. Hakki
A1 Leemans, C. René
A1 van Dongen, Guus A.M.S.
A1 de Bree, Remco
YR 2013
UL http://jnm.snmjournals.org/content/54/4/585.abstract
AB With conventional imaging techniques such as planar lymphoscintigraphy and SPECT/CT, preoperative sentinel node (SN) identification can be difficult when the SN is near the primary tumor, as is the case in floor-of-mouth carcinomas. PET/CT lymphoscintigraphy may improve the detection and localization of such SNs. Methods: In this study, the clinical feasibility of PET/CT lymphoscintigraphy using 89Zr-nanocolloidal albumin was evaluated in 5 oral cancer patients. PET/CT lymphoscintigraphy was performed after peritumoral injection of 89Zr-nanocolloidal albumin. The routine SN procedure, including SPECT/CT using 99mTc-nanocolloidal albumin, was performed on the same patients 7–9 d after the injection of 89Zr-nanocolloidal albumin. Results: Comparison of radiocolloid distribution on PET/CT and SPECT/CT showed identical drainage patterns. Moreover, PET/CT was able to identify additional foci near the primary tumor. Conclusion: This pilot PET/CT study on SN detection indicated that lymphoscintigraphy using 89Zr-nanocolloidal albumin is feasible.