RT Journal Article SR Electronic T1 PET/MRI for Neurologic Applications JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1916 OP 1925 DO 10.2967/jnumed.112.105346 VO 53 IS 12 A1 Ciprian Catana A1 Alexander Drzezga A1 Wolf-Dieter Heiss A1 Bruce R. Rosen YR 2012 UL http://jnm.snmjournals.org/content/53/12/1916.abstract AB PET and MRI provide complementary information in the study of the human brain. Simultaneous PET/MRI data acquisition allows the spatial and temporal correlation of the measured signals, creating opportunities impossible to realize using stand-alone instruments. This paper reviews the methodologic improvements and potential neurologic and psychiatric applications of this novel technology. We first present methods for improving the performance and information content of each modality by using the information provided by the other technique. On the PET side, we discuss methods that use the simultaneously acquired MRI data to improve the PET data quantification. On the MRI side, we present how improved PET quantification can be used to validate several MRI techniques. Finally, we describe promising research, translational, and clinical applications that can benefit from these advanced tools.