TY - JOUR T1 - Sex and SUVmax: Sex-Dependent Prognostication in Early Non–Small Cell Lung Cancer JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1676 LP - 1685 DO - 10.2967/jnumed.112.105197 VL - 53 IS - 11 AU - Zoe Wainer AU - Marissa G. Daniels AU - Jason Callahan AU - David Binns AU - Rodney J. Hicks AU - Phillip Antippa AU - Prudence A. Russell AU - Naveed Z. Alam AU - Matthew Conron AU - Benjamin Solomon AU - Gavin M. Wright Y1 - 2012/11/01 UR - http://jnm.snmjournals.org/content/53/11/1676.abstract N2 - The identification of robust prognostic factors for patients with early-stage non–small cell lung cancer (NSCLC) is clinically important. The International Association for the Study of Lung Cancer has identified both sex and the maximum standardized uptake value (SUVmax) of 18F-FDG in the primary tumor as measured by PET as potential prognostic variables. We examined the prognostic value of SUVmax in a surgical cohort of patients with NSCLC and disaggregated the findings by sex. Methods: Patients who had undergone a preoperative PET/CT scan and surgical resection with curative intent from 2001 to 2009 were identified from a prospective database. An SUVmax cutoff was calculated using receiver-operating-characteristic curves. Overall survival was correlated with SUVmax for the whole cohort and disaggregated by sex. Results: Inclusion criteria were met by 189 patients: 127 (67%) men and 62 (33%) women. Five-year survival was 54.6% for the whole cohort, 47.7% for men, and 68.2% for women. SUVmax correlated negatively with survival in a univariate analysis for the whole cohort (hazard ratio [HR], 2.51; 95% confidence interval [CI], 1.54–4.09; P < 0.001) and men (HR, 3.42; 95% CI, 1.94–6.05; P < 0.001) but not for women (HR, 1.61; 95% CI, 0.43–3.12; P = 0.77), using 8 as a cutoff. In multivariate analysis, SUVmax correlated with overall survival for the whole cohort (HR, 1.70; 95% CI, 1.05–2.99; P = 0.05) and men (HR, 2.40; 95% CI, 1.32–4.37; P = 0.004) but not for women (HR, 0.80; 95% CI, 0.15–4.47; P = 0.80). Conclusion: SUVmax independently predicted overall survival for men but not for women in this surgical cohort. Our results suggest that SUVmax is an independent prognostic variable in men with surgically treated early NSCLC. ER -