RT Journal Article SR Electronic T1 Utility of 18F-Fluoride PET/CT and 18F-FDG PET/CT in the Detection of Bony Metastases in Heightened-Risk Head and Neck Cancer Patients JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 1730 OP 1735 DO 10.2967/jnumed.112.104893 VO 53 IS 11 A1 Sheng-Chieh Chan A1 Hung-Ming Wang A1 Shu-Hang Ng A1 Cheng-Lung Hsu A1 Yu-Jr Lin A1 Chien-Yu Lin A1 Chun-Ta Liao A1 Tzu-Chen Yen YR 2012 UL http://jnm.snmjournals.org/content/53/11/1730.abstract AB This study compared the diagnostic accuracy of 18F-FDG PET/CT with that of 18F-fluoride PET/CT in the detection of bony metastases in heightened-risk head and neck cancer patients. Methods: The study participants underwent 18F-FDG PET/CT and 18F-fluoride PET/CT within 2 wk of each another. Results: A total of 98 bony metastases were found in 18 of our 80 patients. 18F-fluoride PET/CT and 18F-FDG PET/CT showed similar lesion-based sensitivity (69.4% vs. 57.1%, P = 0.126) and areas under the curve (0.7561 vs. 0.7959, P = 0.149). Their combined interpretation demonstrated a significantly greater sensitivity and areas under the curve than that obtained with either modality alone (P < 0.001) in lesion-based analysis but not in patient-based analysis, with a treatment strategy change in 2 patients. Conclusion: 18F-fluoride PET/CT is a feasible modality for detecting bony metastases in patients with head and neck cancers, with similar sensitivity to 18F-FDG PET/CT. Their combined use may not be justifiable.