RT Journal Article SR Electronic T1 A Compartmental Model for Biokinetics and Dosimetry of 18F-Choline in Prostate Cancer Patients JF Journal of Nuclear Medicine JO J Nucl Med FD Society of Nuclear Medicine SP 985 OP 993 DO 10.2967/jnumed.111.099408 VO 53 IS 6 A1 Augusto Giussani A1 Tilman Janzen A1 Helena Uusijärvi-Lizana A1 Federico Tavola A1 Maria Zankl A1 Marie Sydoff A1 Anders Bjartell A1 Sigrid Leide-Svegborn A1 Marcus Söderberg A1 Sören Mattsson A1 Christoph Hoeschen A1 Marie-Claire Cantone YR 2012 UL http://jnm.snmjournals.org/content/53/6/985.abstract AB PET with 18F-choline (18F-FCH) is used in the diagnosis of prostate cancer and its recurrences. In this work, biodistribution data from a recent study conducted at Skåne University Hospital Malmö were used for the development of a biokinetic and dosimetric model. Methods: The biodistribution of 18F-FCH was followed for 10 patients using PET up to 4 h after administration. Activity concentrations in blood and urine samples were also determined. A compartmental model structure was developed, and values of the model parameters were obtained for each single patient and for a reference patient using a population kinetic approach. Radiation doses to the organs were determined using computational (voxel) phantoms for the determination of the S factors. Results: The model structure consists of a central exchange compartment (blood), 2 compartments each for the liver and kidneys, 1 for spleen, 1 for urinary bladder, and 1 generic compartment accounting for the remaining material. The model can successfully describe the individual patients’ data. The parameters showing the greatest interindividual variations are the blood volume (the clearance process is rapid, and early blood data are not available for several patients) and the transfer out from liver (the physical half-life of 18F is too short to follow this long-term process with the necessary accuracy). The organs receiving the highest doses are the kidneys (reference patient, 0.079 mGy/MBq; individual values, 0.033–0.105 mGy/MBq) and the liver (reference patient, 0.062 mGy/MBq; individual values, 0.036–0.082 mGy/MBq). The dose to the urinary bladder wall of the reference patient varies between 0.017 and 0.030 mGy/MBq, depending on the assumptions on bladder voiding. Conclusion: The model gives a satisfactory description of the biodistribution of 18F-FCH and realistic estimates of the radiation dose received by the patients.