TY - JOUR T1 - Age Effects on Serotonin Receptor 1B as Assessed by PET JF - Journal of Nuclear Medicine JO - J Nucl Med SP - 1411 LP - 1414 DO - 10.2967/jnumed.112.103598 VL - 53 IS - 9 AU - David Matuskey AU - Brian Pittman AU - Beata Planeta-Wilson AU - Espen Walderhaug AU - Shannan Henry AU - Jean-Dominique Gallezot AU - Nabeel Nabulsi AU - Yu-Shin Ding AU - Zubin Bhagwagar AU - Robert Malison AU - Richard E. Carson AU - Alexander Neumeister Y1 - 2012/09/01 UR - http://jnm.snmjournals.org/content/53/9/1411.abstract N2 - Previous imaging studies have suggested that there is an age-related decline in brain serotonin (5-hydroxytryptamine) measures in healthy subjects. This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT1B) is seen to decrease with aging via PET imaging. Methods: Forty-eight healthy control subjects (mean age ± SD, 30 ± 10 y; age range, 18–61 y; 33 men, 15 women) underwent 11C-P943 scanning on a high-resolution PET tomograph. Regions were examined with and without gray matter masking, the latter in an attempt to control for age-related gray matter atrophy on nondisplaceable binding potential (BPND) as determined by a validated multilinear reference tissue model. Results: 5-HT1B BPND decreased in the cortex at an average rate of 8% per decade without and 9% with gray matter masking. A negative association with age was also observed in all individual cortical regions. Differences in the putamen and pallidum (positive association) were significant after adjustment for multiple comparisons. No sex- or race-related effects on 5-HT1B BPND were found in any regions. Conclusion: These findings indicate that age is a relevant factor for 5-HT1B in the cortex of healthy adults. ER -