RT Journal Article
SR Electronic
T1 Age Effects on Serotonin Receptor 1B as Assessed by PET
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1411
OP 1414
DO 10.2967/jnumed.112.103598
VO 53
IS 9
A1 Matuskey, David
A1 Pittman, Brian
A1 Planeta-Wilson, Beata
A1 Walderhaug, Espen
A1 Henry, Shannan
A1 Gallezot, Jean-Dominique
A1 Nabulsi, Nabeel
A1 Ding, Yu-Shin
A1 Bhagwagar, Zubin
A1 Malison, Robert
A1 Carson, Richard E.
A1 Neumeister, Alexander
YR 2012
UL http://jnm.snmjournals.org/content/53/9/1411.abstract
AB Previous imaging studies have suggested that there is an age-related decline in brain serotonin (5-hydroxytryptamine) measures in healthy subjects. This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT1B) is seen to decrease with aging via PET imaging. Methods: Forty-eight healthy control subjects (mean age ± SD, 30 ± 10 y; age range, 18–61 y; 33 men, 15 women) underwent 11C-P943 scanning on a high-resolution PET tomograph. Regions were examined with and without gray matter masking, the latter in an attempt to control for age-related gray matter atrophy on nondisplaceable binding potential (BPND) as determined by a validated multilinear reference tissue model. Results: 5-HT1B BPND decreased in the cortex at an average rate of 8% per decade without and 9% with gray matter masking. A negative association with age was also observed in all individual cortical regions. Differences in the putamen and pallidum (positive association) were significant after adjustment for multiple comparisons. No sex- or race-related effects on 5-HT1B BPND were found in any regions. Conclusion: These findings indicate that age is a relevant factor for 5-HT1B in the cortex of healthy adults.