PT  - JOURNAL ARTICLE
AU  - Matuskey, David
AU  - Pittman, Brian
AU  - Planeta-Wilson, Beata
AU  - Walderhaug, Espen
AU  - Henry, Shannan
AU  - Gallezot, Jean-Dominique
AU  - Nabulsi, Nabeel
AU  - Ding, Yu-Shin
AU  - Bhagwagar, Zubin
AU  - Malison, Robert
AU  - Carson, Richard E.
AU  - Neumeister, Alexander
TI  - Age Effects on Serotonin Receptor 1B as Assessed by PET
AID  - 10.2967/jnumed.112.103598
DP  - 2012 Sep 01
TA  - Journal of Nuclear Medicine
PG  - 1411--1414
VI  - 53
IP  - 9
4099  - http://jnm.snmjournals.org/content/53/9/1411.short
4100  - http://jnm.snmjournals.org/content/53/9/1411.full
SO  - J Nucl Med2012 Sep 01; 53
AB  - Previous imaging studies have suggested that there is an age-related decline in brain serotonin (5-hydroxytryptamine) measures in healthy subjects. This paper addresses whether the availability of 5-hydroxytryptamine receptor 1B (5-HT1B) is seen to decrease with aging via PET imaging. Methods: Forty-eight healthy control subjects (mean age ± SD, 30 ± 10 y; age range, 18–61 y; 33 men, 15 women) underwent 11C-P943 scanning on a high-resolution PET tomograph. Regions were examined with and without gray matter masking, the latter in an attempt to control for age-related gray matter atrophy on nondisplaceable binding potential (BPND) as determined by a validated multilinear reference tissue model. Results: 5-HT1B BPND decreased in the cortex at an average rate of 8% per decade without and 9% with gray matter masking. A negative association with age was also observed in all individual cortical regions. Differences in the putamen and pallidum (positive association) were significant after adjustment for multiple comparisons. No sex- or race-related effects on 5-HT1B BPND were found in any regions. Conclusion: These findings indicate that age is a relevant factor for 5-HT1B in the cortex of healthy adults.