RT Journal Article
SR Electronic
T1 Fasting and Postprandial Activity of Brown Adipose Tissue in Healthy Men
JF Journal of Nuclear Medicine
JO J Nucl Med
FD Society of Nuclear Medicine
SP 1407
OP 1410
DO 10.2967/jnumed.111.100701
VO 53
IS 9
A1 Anne Vrieze
A1 Josefine E. Schopman
A1 Wanda M. Admiraal
A1 Maarten R. Soeters
A1 Max Nieuwdorp
A1 Hein J. Verberne
A1 Frits Holleman
YR 2012
UL http://jnm.snmjournals.org/content/53/9/1407.abstract
AB The role of brown adipose tissue (BAT) in adult metabolism is poorly understood. This study aimed to examine the differential effects of an overnight fast and the postprandial state on BAT activity. Methods: We included 10 healthy, lean male volunteers. BAT uptake of glucose was visualized using 18F-FDG PET/CT during mild cold exposure. Each subject underwent PET/CT twice. The first scan was obtained after an overnight fast; the second after a standardized meal. Results: 18F-FDG uptake in BAT was observed in 6 of 10 volunteers. These subjects were found to have a higher maximal standardized uptake value when fasting (median, 13.1 g/mL; range, 6.1–27.6 g/mL) than when in the postprandial state (median, 6.8 g/mL; range, 2.1–13.4 g/mL) (P = 0.03). Conclusion: Cold-stimulated 18F-FDG uptake by BAT in humans is more pronounced during fasting. The lower maximal standardized uptake value in the postprandial state may be explained by increased insulin-stimulated glucose uptake in muscle.